Posted by jayaram in Luft’s Diseases
In 1962 Luft’s diseases was introduced in mitochondrial energy transduction. Increases in BMR (basal metabolic rate), inspite of taking high caloric food the person body weight does’nt get increased these are the general symptoms of Luft’s diseases. The Luft’s diseases are widely seen in the patients who those have defects in the mechanism of mitochondrial oxygen utilization. After the invention of Luft disease in 1962, scientists found more of this kind of mitochodrial genetic diseases. When the genetic abnormalities in the mitochondria seen that leads to alterations in a membrane transport systems, electron transport system, in enzymes and RNA (ribonucleic acids). The genetic diseases in the mitochondrial mainly caused due to the sudden change of nuclear DNA as well as mitochondrial DNA.
The Leber’s hereditary optic neuropathy
The Leber’s hereditary optic neuropathy is the first disease due to the sudden change of mitochondrial DNA. The Leber’s hereditary optic neuropathy diseases can affect the skeletal muscle and central nervous system or optic nerves that lead to the sudden blindness in the early aged people due to their damage in the optic nerve. The diseases resulting from sudden change in mitochondrial DNA is depended on the mutated mitochondrial DNA that is present in a given tissue or cell.
Dystonia
The more deleterious effects in energy production on the mitochondria are due to the mutant mitochondrial DNA in the tissue. The sudden onset blindness in early aged people is due to the lower percentage of mutant mitochondrial DNA. The disease dystonia is caused due to their higher percentage of mutant mitochondrial DNA in the affected patients. Dystonia is a severe disease that leads to impaired speech, early onset of generalized movement disorder, and mental retardation.
The mutation of mitochondrial DNA is due to the formation of superoxide (free radicals) in the mitochondria. The damage in the mitochondrial DNA may leads to the several diseases namely cardiomyopathies, Alzheimer’s diseases and Parkinson disease.